Transglutaminase IgA

Faecal anti-tissue transglutaminase IgA antibodies indicate a reaction of the immune system to the tissue transglutaminase enzyme produced by the body when gluten is ingested, leading to an autoimmune reaction that may destroy the intestinal lining or other tissues in the body.

Stool analysis for antibodies against gluten-related antigens may be a more sensitive assessment to gluten/immune reactions than serum antibody assessments. Positive faecal anti-tissue transglutaminase IgA (produced in situ by the intestinal mucosal) result from a specific immune reaction to gluten in the digestive tract, and may be present in the absence of similar antibodies in serum, especially in the absence of the typical coeliac disease-related damage to the intestinal tract (i.e., villous atrophy). This represents the immune/inflammatory response to gluten that may be ongoing without any apparent damage to the gut or without any elevated serum antibody titres. Intestinal gluten antibody assessments may be a more accurate method of detecting gluten intolerance reactions, and may reflect such immune reaction before, or in the absence of any traditional serum evaluations.

Test details

• Test code: 2016
• Category: Microbiome Health
• Kit requirements: Stool Test Kit
• Collection method: CI05.34.01
• Test method: FEIA (Fluorescence immunoassay)
• Turnaround time: 3-5 Business Days

What is measured

• Transglutaminase IgA - gluten sensitivity marker

Common clinical applications

• Gastrointestinal and Digestive Health
  • Bloating
• Other Health Conditions
  • Chronic Fatigue, Fibromyalgia
  • Diarrhoea
  • Flatulence
  • Food sensitivities
  • Indigestion
  • Irritable Bowel Syndrome
• Skin and Dermatological Health
  • Eczema, Psoriasis

Resources

• Patient Brochure
• Sample Report

This test should be ordered and interpreted with guidance from a qualified healthcare practitioner.

Important: Test information is general only. Results should be interpreted with a qualified health practitioner and do not replace medical advice or diagnosis.