Ingredients

Other Ingredients: Vegetable cellulose (hypromellose); Vegetable Stearic Acid; Microcrystalline Cellulose and Vegetable Magnesium Stearate.

Does not contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts

Actions & Indications

TANSHINS

90 x 500 mg Capsules

Actions

Anti-inflammatory

Cell-cycle arrest

Inhibits dihydrotestosterone (DHT)

Anti-proliferative

Hepato-protective

Anti-angiogenic

Anti-atherosclerotic

Induces apoptosis

Anti-tumour

Indications

Prostate cancer

Breast cancer (ER+, ER-)

Cervical cancer

Leukaemia

Chronic Myeloid

Hepatocellular cancer

Colorectal cancer

NSCLC cancer

Alzheimer’s disease

Combinations:

Cancer protocols

Suggested Use:

3 Capsules 3 times daily

Caution:

Effects of TANSHINS on Cytochrome P450 Isoforms. The cytochrome P450 enzymes are found primarily in the liver. TANSHINS (CTS) significantly increased the activity of CYP1A2 in a dose-dependent manner. In CTS groups at the dosages of 20 ~ 540 mg/kg, the activity of CYP1A2 was 60 % ~ 430 % higher, CYP1A2 protein expression level was 130 % ~ 320 % higher, and CYP1A2 mRNA expression level was 10 % ~ 150 % higher than that of the negative control group. CTS had no effect on other kinds of CYP isoforms. CTS can induce hepatic microsome CYP1A2 expression significantly, which indicates potential drug-drug interaction might occur when CTS is co-administrated with those drugs metabolised by CYP1A2 such as Capecitabine / Capecitabine (Xeloda), Lapatinib / Lapatinib (Tykerb) Traditional Chinese Drug Research & Clinical Pharmacology 2009-04, DOI CNKI:SUN:ZYXY.0.2009-04-012