Organic Acids Metabolomic Mapping

The Organic Acids Metabolomic Profile is a nutritional assessment providing insights into organic acids and a view into the body’s cellular metabolic processes. Additionally, children’s reference ranges are designed to provide more accurate paediatric nutritional evaluations. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions that maximise patient responses and lead to improved patient outcomes.

The Organic Acids Metabolomic profile provides vital patient information from a single urine specimen. This organic acids nutritional test is valuable for determining:

• Identifying the body’s functional needs:
  •   for specific Vitamins, minerals, and amino acids through identifying blockages within their biochemical metabolic pathways;
  •   for specific biochemical cofactors to optimise healthy metabolism (Lipoic Acid, CoQ10, Carnitine, NAC, etc.);
  •   for specific antioxidant needs and potential Oxidative Damage.
•  Identifying Detoxification capacity
•  Identifying appropriate Neurotransmitter metabolism
•  Assessing Mitochondrial energy production/capacity
•  Assessing Methylation status
•  Identifying possible bacterial and yeast overgrowth/dysbiosis
•  Oxalate metabolism markers
• Environmental Exposures

Test details

• Test code: 4041
• Category: Mental Health
• Kit requirements: Spot Urine
• Collection method: CI05.12.01
• Test method: LCMS/MS/MS (Liquid chromatography mass spectrometry)
• Turnaround time: 14 Business Days

What is measured

• 2-Hydroxybutyric Acid
• 2-Hydroxyglutaric Acid (alpha-Hydroxyglutaric acid)
• 2-Hydroxyhippuric acid (Salicyluric) (2-HHA)
• 2-Hydroxyisobutyric Acid
• 2-Hydroxyisocaproic Acid
• 2-Hydroxyisovaleric Acid
• 2-Hydroxyphenylacetic Acid (2-HPAA)
• 2-Methylglutaric Acid (Methylglutaric Acid)
• 2-Methylhippuric Acid
• 2-Oxo-4-methiolbutyric Acid (KMBA)
• 2-Oxoadipic Acid (Alpha-Ketoadipic Acid)
• 2-Oxobutyric Acid (Alpha-Ketobutyric Acid)
• 2-Oxoglutaric Acid
• 2-Oxoisocaproic Acid
• 2-Oxoisovaleric Acid
• 2,4-Dihydroxybutanoic Acid
• 3-(3-Hydroxyphenyl)-3-Hydroxypropionic Acid (HPHPA)
• 3-Hydroxy-3-methylglutaric Acid (CoQ10)
• 3-Hydroxybutyric Acid
• 3-hydroxyglutaric Acid
• 3-Hydroxyisovaleric Acid (2-Hydroxy-3-Methylbutyric Acid)
• 3-Hydroxyphenylacetic Acid (3-HPAA)
• 3-Hydroxypropionic Acid (3-HPA)
• 3-Methyl-2-oxovaleric Acid
• 3-Methyl-4-hydroxyphenylglycol (MHPG)
• 3-methyl-4-OH-phenylglycol (MHPG)
• 3-Methylcrotonylglycine
• 3-Methylglutaconic Acid
• 3-Methylglutaric Acid
• 3-Methylhippuric Acid
• 3-OH-Proprionic Acid
• 3-Oxoglutaric Acid
• 3-Phenyllactic Acid (3-PLA)
• 3,4-Dihydrophenylacetic Acid (DOPAC)
• 3,4-Dihydroxybenzoic Acid (3,4-DHBA)
• 3,4-Dihydroxyphenylacetic Acid (DOPAC)
• 3,4-Dihydroxyphenylpropionic Acid (DHPPA)
• 3,4-Dimethylhippuric Acid
• 3,5-Dihydroxybenzoic Acid
• 4-Cresol
• 4-Hydroxybenzoic Acid (4-HBA)
• 4-Hydroxybutyric Acid
• 4-Hydroxyhippuric Acid
• 4-Hydroxyphenylacetic Acid (4-HPAA)
• 4-Hydroxyphenyllactic Acid (4-HPLA)
• 4-Methylhippuric Acid
• 5-Hydroxyindoleacetic Acid (5HIAA)
• 5-Hydroxymethyl-2-furoic acid (5-HMFA)
• 5-Methylcytosine (5-MC)
• 8-Hydroxy-2-deoxyguanosine (8-OHdG)
• 8-OH-deoxyguanosine
• a-Keto-b-Methylvaleric Acid
• a-Ketoglutaric Acid
• a-Ketoisocaproic Acid
• a-Ketoisovaleric Acid
• a-OH-Butyric Acid
• Acetoacetic acid (AcAc)
• Adipic Acid
• Aldosterone
• Arabinitol
• Arabinose
• Ascorbic Acid (Vit C)
• Azelaic acid
• b-OH-b-Methylglutaric Acid
• b-OH-Butyric Acid
• Benzoate (OA)
• Benzoic Acid
• beta-Hydroxyisovaleric Acid
• Biotin (Vit H)
• Carboxycitric Acid
• cis-Aconitic Acid
• Citramalic Acid
• Citric Acid
• Citric acid cycle metabolites
• CoEnzyme-Q10 (CoQ10)
• Cortisol (OA)
• Cortisol/Cortisone Ratio
• Creatinine
• Dihydroxyphenylpropionic Acid
• Equol (Isoflavone metabolite)
• Ethylmalonic Acid
• Formiminoglutamic Acid (FIGLU)
• Fructose
• Fumaric Acid
• Furan-2,5-dicarboxylic acid (FDCA)
• Furancarbonylglycine (FCG)
• Glucaric Acid
• Glucose (OA)
• Glutaric Acid (Vit B2)
• Glyceric Acid
• Glycolic Acid
• Guanidinoacetic acid (GAA)
• Guanidinobutyric acid (GBA)
• Hexanoylglycine
• Hippurate (OA)
• Hippuric Acid
• Homogentisic acid (HGA)
• Homovanillic Acid (HVA)
• HVA/DOPAC Ratio
• HVA/VMA Ratio
• Indoleacetic Acid
• Isocitric Acid
• Isovalerylglycine
• Ketone/fatty acid metabolites
• Kynurenic Acid
• Kynurenic/Quinolinic Ratio
• L. acidophilus/General Bacteria
• Lactic Acid
• Leukotriene E4 (LTE4)
• m-Cresol-sulphate
• Malic Acid
• Malonic Acid
• Mandelic Acid
• Methyl-Succinic Acid
• Methylcitric Acid (Biotin)
• Methylcystine
• Methylmalonic Acid (MMA)
• Mevalonolactone
• Microalbumin
• Monoethyl Phthalate
• N-(2-Methylbutyryl)glycine (2-MBG)
• N-Acetyl-Phenylalanine
• N-Acetylaspartic acid (NAA)
• N-Acetylcysteine (NAC)
• N-Acetylglycine (NAG)
• N-Butyrylglycine (NBG)
• Organic acids
• Orotic Acid
• Oxalic Acid
• p-HydroxyPhenylacetate
• Pantothenic Acid (Vit B5)
• ParaHydroxyBenzoate
• ParaHydroxyphenyllactate
• pH
• Phenylacetate
• Phenylacetic Acid (PAA)
• Phenylglyoxylic Acid
• Phenylpropionate
• Phenylpropionic Acid (N-(3-Phenylpropionyl) glycine)
• Phenylpyruvic acid
• Phosphate
• Phosphoric Acid
• Phthalic Acid
• Picolinic Acid
• Pimelic Acid
• Propionylglycine (2-Propanamidoacetic acid)
• Pyridoxic Acid (Vit B6)
• Pyroglutamic Acid
• Pyruvic Acid
• QUERCETIN
• Quinolinic Acid (OA)
• Quinolinic Acid/5-HIAA Ratio
• Sebacic Acid
• Suberic Acid
• Suberylglycine
• Succinic Acid
• Succinylacetone (4,6-Dioxoheptanoic acid)
• t,t-Muconic Acid
• Tartaric Acid
• Thymine
• Tiglylglycine
• Tricarballylate
• Tricarballylic Acid
• Uracil
• Vanillylmandelic Acid (VMA)
• Xanthurenic Acid

Resources

• Patient Brochure
• Sample Report

This test should be ordered and interpreted with guidance from a qualified healthcare practitioner.

Important: Test information is general only. Results should be interpreted with a qualified health practitioner and do not replace medical advice or diagnosis.