M2 Pyruvate Kinase (M2-PK)

M2 Pyruvate Kinase (M2-PK), as measured in faeces, is a tumour marker for colorectal cancer.  Though M2-PK can be elevated in many tumour types, rather than being an organ-specific tumour marker, increased stool (faecal) levels can be used as a early detection of colorectal carcinomas.

The detection of M2-PK does not depend on blood in the stool and is specifically related to changes in tumour metabolism. The M2-PK test is a non-invasive stool test that can be used for the early detection of colorectal cancers and polyps which are known to be the precursors of colorectal cancer.

Increased M2-PK values can sometimes also occur in severe inflammatory diseases which must be excluded by differential diagnosis. If elevated levels of M2PK are present, it is recommended to request more specific tumour marker tests such as (CEA) for bowel cancer, CA 19-9 for pancreatic cancer and CA 72-4 for gastric cancer. This will significantly increase the sensitivity to detect various cancers.

M2PK can be ordered as a single marker or in alliance with a CDSA panel that includes certain GIT markers.

Test details

• Test code: 2012
• Category: Microbiome Health
• Kit requirements: Stool Test Kit
• Collection method: CI05.34.01
• Test method: EIA (Enzyme immunoassay)
• Turnaround time: 3-5 Business Days

What is measured

• M2 Pyruvate Kinase (M2-PK)

Common clinical applications

• Gastrointestinal and Digestive Health
  • Bloating, pain or nausea
  • Cholecystectomy
  • Gastroesophageal reflux symptoms
  • Loose or watery stools
  • Undigested food in the stool
• Endocrine and Hormonal Health
  • Diabetes
  • Hypochlorhydria
• Other Health Conditions
  • Food intolerances
  • Osteoporosis

Resources

• Patient Brochure
• Sample Report

This test should be ordered and interpreted with guidance from a qualified healthcare practitioner.

Important: Test information is general only. Results should be interpreted with a qualified health practitioner and do not replace medical advice or diagnosis.