Ingredients

CNS Factor combination has been researched increase Brain-derived neurotrophic factor (BDNF) levels in the brain. A key ingredient Schisandrin B a well-known adaptogen, cognitive aid, neuroprotective, mood balancing and anti-inflammatory effects.*

Other Ingredients: Vegetable cellulose (hypromellose); Vegetable Stearic Acid; Microcrystalline Cellulose and Vegetable Magnesium Stearate.

Does Not Contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts.

Actions & Indications

CNS Factor (NeuroFactor)

120 x 500 mg Capsules

Actions

Anti-depressant

Anxiolytic

Adaptogen

Reduces effects of stress

Improves memory, cognition and attention

Regulates heathy sleep cycle

Increases Brain-derived neurotrophic Factors (BDNF)

Regulates stress hormone production

Reduces serum levels of cortistatin, adrenocorticotropic hormone (ACTH), and corticotropin-releasing factor (CRF)

Upregulates GABAA receptors

Reduces glutamic acid levels

Increases serotonin

Indications

Depression (Treatment-Resistant Depression (TRD))

Anxiety

Chronic stress

Stress related memory impairment

Cognitive impairment

Neurodegenerative conditions

Suggested use: 3-4 capsules daily

Cautions and Contraindications

Caution in pregnancy.

Schisandra may affect medications metabolized by the liver enzymes Cytochrome P450 1A2, 2C9, 3A4, and 3A5 substrates: medications changed by the liver include celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), and warfarin (Coumadin). The doses of the medication might need to be changed.

Schisandra may have inhibitory effects on the liver enzyme Cytochrome P450 3A4. Medications metabolized by CYP 450 3A4 include Alprazolam (Xanax), amlodipine (Norvasc), atorvastatin (Lipitor), cyclosporine (Sandimmune), diazepam (Valium), estradiol (Estrace), simvastatin (Zocor), sildenafil (Viagra), verapamil, zolpidem (Ambien)

Warfarin (Coumadin) interacts with schisandra: Warfarin (Coumadin) is used to slow blood clotting. The body breaks down warfarin (Coumadin) to get rid of it. Schisandra might increase the breakdown and decrease the effectiveness of warfarin (Coumadin). Decreasing the effectiveness of warfarin (Coumadin) might increase the risk of clotting. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.

Anti-epileptic drugs: Benzodiazepines are one of the most common. NeuroFactor is an agonist and will cause drowsiness, and therefore needs to be monitored.

May increase effect of Benzodiazepine drugs however, it’s not contraindicated. Schisandra has been used for Benzodiazepine withdrawal.

Supports SSRIs.

P-glycoprotein substrates: Lab and human studies suggest schisandra can inhibit Pgp activity and may interfere with the metabolism of certain drugs.

Tacrolimus: In liver transplant patients, schisandra increased blood levels of tacrolimus, an immunosuppressant.