Fatigue Syndrome - Re)Boot

Re)Boot

60 Capsules

Actions

• Relieves mental and physical fatigue

• Enhances mental function and memory function

• Supports healthy gastrointestinal function

• Stimulates HPA Axis

• Increases release of ACTH

Indications

• Physical and mental fatigue

• Age-related fatigue

• Age-related memory loss

Ingredients

Panax ginseng - root

Atractylodes macrocephala - root

Dioscorea oppositifolia - root

Inula helenium - root

Citrus aurantium - fruit peel

Angelica polymorpha - root

Amomum villosum - fruit

Astragalus membranaceus - root

Ziziphus jujuba var. spinosa - seed

Polygala tenuifolia - root

Coptis chinensis - root

Panax quinquefolius - fruit

Does not contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts 

Caution: Do not take during Flu or Colds

Suggested Use

2-3 Capsules twice daily

Key Ingredients

Panax Ginseng

Panax ginseng (PG, Asian ginseng) is a popular traditional Chinese medicine in which the active ingredient is the ginsenosides. Numerous studies support Asian ginseng’s effectiveness at improving a person’s ability to withstand stress, improve work performance and quality, and enhance mental function. The herb has been reported to stimulate the hypothalamo-pituitary-adrenal (HPA) axis and increase the release of adrenocorticotropic hormone (ACTH) thus increasing adrenal hormone secretion. It also can counteract the shrinkage of the adrenal gland caused by corticosteroid drugs. In a recent in vitro study, it was found that Asian ginseng extract inhibited hydroxyl radical formation and they hypothesized that this antioxidant effect may be responsible for ginseng’s wide range of pharmacological uses (1).  Ginseng polysaccharides have anti-fatigue activity, also reflected in the effects on the physiological markers for fatigue (2).

References

1. Ray, A., K. Gulati, and R. Anand. "Stress, Adaptogens and Their Evaluation: An Overview." J Pharma Reports 1.110 (2016): 2.

2. Wang J, Li S, Fan Y, Chen Y, Liu D, Cheng H, Gao X, Zhou Y. Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng C. A. Meyer. J Ethnopharmacol. 2010 Jul 20;130(2):421-3. doi: 10.1016/j.jep.2010.05.027. Epub 2010 May 24. PubMed PMID: 20580802.

Panax quinquefolius

This randomised, double-blind, placebo-controlled, crossover trial (N = 32, healthy young adults) assessed the acute mood, neurocognitive and glycaemic effects of three doses (100, 200 400 mg) of Cereboost™ (P. quinquefolius standardised to 10.65% ginsenosides). Participants' mood, cognitive function and blood glucose were measured 1, 3 and 6 h following administration.

Results

There was a significant improvement of working memory (WM) performance associated with P. quinquefolius. Corsi block performance was improved by all doses at all testing times. There were differential effects of all doses on other WM tasks, which were maintained across the testing day. Choice reaction time accuracy and ‘calmness’ were significantly improved by 100 mg. There were no changes in blood glucose levels.

Conclusions

This preliminary study has identified robust working memory enhancement following administration of American ginseng. These effects are distinct from those of Asian ginseng and suggest that psychopharmacological properties depend critically on ginsenoside profiles. These results have ramifications for the psychopharmacology of herbal extracts and merit further study using different dosing regimens and in populations where cognition is fragile.

Scholey, A., Ossoukhova, A., Owen, L. et al. Psychopharmacology (2010) 212: 345. doi:10.1007/s00213-010-1964-y. Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study

Polygala tenuifolia

Roots of Polygala tenuifolia Willdenow have been used in humans for centuries because of its sedative effects. We previously reported that BT-11, extracted from the roots of the plant, improved memory impairments in rats, enhanced memory in normal humans, and inhibited acetylcholinesterase activities in vitro. The present study was a randomized, double-blind, placebo-controlled comparison study to investigate whether BT-11 could enhance memory in the elderly humans. We used the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD) and the Mini-Mental State Examination (MMSE). In the elderly, the total CERAD scores were much more significantly increased in the BT-11-treated group (n=28) than in the placebo-treated group (n=25). Especially, the mean scores of word list recognition, constructional recall and praxis, and modified Boston naming test were markedly improved in BT-11-treated group than in placebo-treated group. In conclusion, BT-11 could enhance some cognitive functions including memory in the elderly humans and therefore may be used as nutraceuticals that provide health benefits, including disease prevention and/or treatment (1)

Four weeks supplementation of BT-11 at 100mg (three times a day for a total dose of 300mg) in otherwise healthy middle aged adults without cognitive impairment found that supplementation was able to increase immediate recall, recognition, and reduce errors in a spatial memory and organization tast (SOPT) but it was ineffective for short and long term free and cued memory recall (K-CVLT) (2).

References

1. Shin KY, Lee JY, Won BY, Jung HY, Chang KA, Koppula S, Suh YH. BT-11 is effective for enhancing cognitive functions in the elderly humans. Neurosci Lett. 2009 Nov 13;465(2):157-9. doi: 10.1016/j.neulet.2009.08.033. Epub 2009 Aug 20.

2. Lee JY, Kim KY, Shin KY, Won BY, Jung HY, Suh YH. Effects of BT-11 on memory in healthy humans. Neurosci Lett. 2009 Apr 24;454(2):111-4. doi:10.1016/j.neulet.2009.03.024. Epub 2009 Mar 11. PubMed PMID: 19429065.